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XSelect CSH C18 Column

C18表面帶電技術；改善峰形，提高載液量；HPLC到UPLC無縫切換。

應用領域

制藥、生物、化工、食品、環境、緝毒

產品概述
應用
配置

XSelect CSH C18 柱是以C18為骨架，CSH C18具有寬泛的選擇性。CSH技術能改善峰形，提高載液量。即使裝填在低分散性的柱體內，

2010年，沃特世推出了新型表面帶電雜化顆粒(CSH?)技術，為雜化顆粒表面賦予少量正電荷。利用這一技術可以使用低離子強度的流動相(如0.1%甲酸體系)分析堿性化合物，而仍能獲得卓越的峰形與載量。CSH技術還允許使用甲酸來替代TFA等離子對試劑，而仍保持帶電分析物的良好峰形，對于質譜分析尤為有利。

XSelect CSH C18 柱在低離子強度流動相條件下(如0.1%甲酸體系)因載量所導致的峰形差問題。因帶有嚴格控制下的、低水平的正表面電荷，該柱為堿性化合物提供的峰行無需使用離子對試劑。

按美國藥典方法及中國藥典方法檢測紫杉醇藥物

紫杉醇（Paclitaxel）最初是從紅豆杉科紅豆杉屬（Taxus）植物的樹皮中提取得到的二萜類化合物，具有獨特抗癌活性，曾被美國國立癌癥研究所認為是近15-20年來腫瘤化療的最重要的進展。紫杉醇注射液功效主治卵巢癌和乳腺癌及NSCLC 的一線和二線治療。頭頸癌、食管癌，精原細胞瘤，復發非何金氏淋巴瘤等。因紫杉醇抗癌療效明確，臨床應用市場容量大，原料藥與制劑藥生產需求持續，對于紫杉醇的新劑型研究以及對紫杉醇同系物的新藥開發也一直在持續進行中。美國藥典方法規定使用L43全氟苯基柱對紫杉醇[1]以及紫杉醇注射液進行含量測定，
系統方法條件如下：流動相：水-乙腈 11:9（即 55:45），如需要時可適當調整比例。洗脫：等度，1.5mL/min[1] 色譜柱：5μm, 4.6[1]或4.0[2] mmID x 250mmL，L43（即：PFP，全氟苯基）檢測：UV 227nm 要求：拖尾因子0.7-1.3范圍內[1]；紫杉醇峰的保留時間在6.0- 10.0min范圍內[2] 美國藥典指導性通則USP Chromatography <621>對色譜方法進行定義并制定了方法實施的指導原則，其中也規定了色譜方法的調整范圍，如果檢測方法調整在此范圍內，即視為仍遵循原方法的法規要求，只要能夠滿足系統適應性要求，就無需進行方法再驗證。液相色譜方法的調整范圍包括不僅限于如下： - 色譜柱粒徑可減小（但減小程度最多為50%） - 柱長度可調整±70% - 流速可調整±50% 使用沃特世最新產品XSelect? HSS PFP色譜柱(3.5μm, 4.6x150mm，PN186005862)，流速1mL/min，對紫杉醇混標進行分離，可達到系統適應性要求，且峰形良好，分離優異。柱規格與流速的改變在通則<621>的限制范圍之內，因此方法仍具有法規依從性。

品名	編號
XSelect CSH C18 Column, 130?, 3.5 μm, 2.1 mm X 50 mm, 1/pkg	186005255
XSelect CSH C18 Column, 130?, 3.5 μm, 2.1 mm X 100 mm, 1/pkg	186005256
XSelect CSH C18 Column, 130?, 3.5 μm, 2.1 mm X 150 mm, 1/pkg	186005257
XSelect CSH C18 Column, 130?, 3.5 μm, 1 mm X 150 mm, 1/pkg	186005251
XSelect CSH C18 Column, 130?, 3.5 μm, 2.1 mm X 20 mm, 1/pkg	186005253
XSelect CSH C18 Column, 130?, 3.5 μm, 2.1 mm X 30 mm, 1/pkg	186005254
XSelect CSH C18 Column, 130?, 3.5 μm, 1 mm X 100 mm, 1/pkg	186005250
XSelect CSH C18 Column, 130?, 3.5 μm, 2.1 mm X 75 mm, 1/pkg	186005644
XSelect CSH C18 Column, 130?, 3.5 μm, 4.6 mm X 150 mm, 1/pkg	186005270
XSelect CSH C18 Column, 130?, 3.5 μm, 3 mm X 75 mm, 1/pkg	186005647
XSelect CSH C18 Column, 130?, 3.5 μm, 3 mm X 20 mm, 1/pkg	186005259
XSelect CSH C18 Column, 130?, 3.5 μm, 4.6 mm X 20 mm, 1/pkg	186005265
XSelect CSH C18 Column, 130?, 3.5 μm, 3 mm X 100 mm, 1/pkg	186005262
XSelect CSH C18 Column, 130?, 3.5 μm, 3 mm X 150 mm, 1/pkg	186005263
XSelect CSH C18 Column, 130?, 3.5 μm, 4.6 mm X 75 mm, 1/pkg	186005268
XSelect CSH C18 Column, 130?, 3.5 μm, 4.6 mm X 100 mm, 1/pkg	186005269
XSelect CSH C18 Column, 130?, 3.5 μm, 4.6 mm X 30 mm, 1/pkg	186005266
XSelect CSH C18 Column, 130?, 3.5 μm, 4.6 mm X 50 mm, 1/pkg	186005267
XSelect CSH C18 Column, 130?, 3.5 μm, 3 mm X 30 mm, 1/pkg	186005260
XSelect CSH C18 Column, 130?, 3.5 μm, 3 mm X 50 mm, 1/pkg	186005261
XSelect CSH C18 Column, 130?, 5 μm, 2.1 mm X 30 mm, 1/pkg	186005273
XSelect CSH C18 Column, 130?, 5 μm, 2.1 mm X 50 mm, 1/pkg	186005274
XSelect CSH C18 Column, 130?, 5 μm, 2.1 mm X 100 mm, 1/pkg	186005275
XSelect CSH C18 Column, 130?, 5 μm, 2.1 mm X 150 mm, 1/pkg	186005276
XSelect CSH C18 Column, 130?, 5 μm, 3 mm X 30 mm, 1/pkg	186005279
XSelect CSH C18 Column, 130?, 5 μm, 4.6 mm X 150 mm, 1/pkg	186005290
XSelect CSH C18 Column, 130?, 5 μm, 4.6 mm X 250 mm, 1/pkg	186005291
XSelect CSH C18 Column, 130?, 5 μm, 2.1 mm X 20 mm, 1/pkg	186005272
XSelect CSH C18 Column, 130?, 5 μm, 4.6 mm X 20 mm, 1/pkg	186005284
XSelect CSH C18 Column, 130?, 5 μm, 4.6 mm X 30 mm, 1/pkg	186005286
XSelect CSH C18 Column, 130?, 5 μm, 4.6 mm X 50 mm, 1/pkg	186005287
XSelect CSH C18 Column, 130?, 5 μm, 4.6 mm X 75 mm, 1/pkg	186005288
XSelect CSH C18 Column, 130?, 5 μm, 4.6 mm X 100 mm, 1/pkg	186005289
XSelect CSH C18 Method Validation Kit, 130?, 2.5 μm, 4.6 mm X 100 mm, 3/pkg	186006238
XSelect CSH C18 Column, 130?, 5 μm, 3 mm X 50 mm, 1/pkg	186005280
XSelect CSH C18 Column, 130?, 5 μm, 3 mm X 100 mm, 1/pkg	186005281
XSelect CSH C18 Column, 130?, 5 μm, 3 mm X 150 mm, 1/pkg	186005282
XSelect CSH C18 Column, 130?, 5 μm, 3 mm X 250 mm, 1/pkg	186005283
XSelect CSH C18 Method Validation Kit, 130?, 2.5 μm, 2.1 mm X 50 mm, 3/pkg	186006233
XSelect CSH C18 Method Validation Kit, 130?, 2.5 μm, 2.1 mm X 150 mm, 3/pkg	186006785
XSelect CSH C18 Method Validation Kit, 130?, 2.5 μm, 3 mm X 150 mm, 3/pkg	186006786
XSelect CSH C18 Method Validation Kit, 130?, 2.5 μm, 4.6 mm X 150 mm, 3/pkg	186006787
XSelect CSH C18 Method Validation Kit, 130?, 2.5 μm, 3 mm X 100 mm, 3/pkg	186006236
XSelect CSH C18 Method Validation Kit, 130?, 2.5 μm, 4.6 mm X 50 mm, 3/pkg	186006237
XSelect CSH C18 Method Validation Kit, 130?, 2.5 μm, 2.1 mm X 100 mm, 3/pkg	186006234
XSelect CSH C18 Method Validation Kit, 130?, 5 μm, 3 mm X 150 mm, 3/pkg	186005545
XSelect CSH C18 Method Validation Kit, 130?, 5 μm, 4.6 mm X 100 mm, 3/pkg	186005546
XSelect CSH C18 Method Validation Kit, 130?, 5 μm, 4.6 mm X 150 mm, 3/pkg	186005547
XSelect CSH C18 Method Validation Kit, 130?, 5 μm, 4.6 mm X 250 mm, 3/pkg	186005548
XSelect CSH C18 OBD Prep Column, 130?, 5 μm, 19 mm X 100 mm, 1/pkg	186005421
XSelect CSH C18 Method Validation Kit, 130?, 3.5 μm, 3 mm X 150 mm, 3/pkg	186005540
XSelect CSH C18 Method Validation Kit, 130?, 3.5 μm, 4.6 mm X 150 mm, 3/pkg	186005542
XSelect CSH C18 Method Validation Kit, 130?, 3.5 μm, 4.6 mm X 100 mm, 3/pkg	186005541
XSelect CSH C18 Method Validation Kit, 130?, 5 μm, 2.1 mm X 150 mm, 3/pkg	186005543
XSelect CSH C18 OBD Prep Column, 130?, 10 μm, 30 mm X 50 mm, 1/pkg	186007296
XSelect CSH C18 OBD Prep Column, 130?, 10 μm, 19 mm X 150 mm, 1/pkg	186007293
XSelect CSH C18 Method Validation Kit, 130?, 3.5 μm, 2.1 mm X 100 mm, 3/pkg	186005538
XSelect CSH C18 OBD Prep Column, 130?, 10 μm, 19 mm X 250 mm, 1/pkg	186007294
XSelect CSH C18 Method Validation Kit, 130?, 3.5 μm, 3 mm X 100 mm, 3/pkg	186005539
XSelect CSH C18 OBD Prep Column, 130?, 10 μm, 19 mm X 50 mm, 1/pkg	186007291
XSelect CSH C18 OBD Prep Column, 130?, 10 μm, 19 mm X 100 mm, 1/pkg	186007292
XSelect CSH C18 OBD Prep Column, 130?, 10 μm, 30 mm X 150 mm, 1/pkg	186007299
XSelect CSH C18 OBD Prep Column, 130?, 10 μm, 30 mm X 75 mm, 1/pkg	186007297
XSelect CSH C18 OBD Prep Column, 130?, 10 μm, 30 mm X 100 mm, 1/pkg	186007298
XSelect CSH C18 Method Validation Kit, XP Column, 130?, 2.5 μm, 3 mm X 50 mm, 3/pkg	186006235
XSelect CSH C18 OBD Prep Column, 130?, 10 μm, 50 mm X 150 mm, 1/pkg	186007303
XSelect CSH C18 OBD Prep Column, 130?, 10 μm, 50 mm X 250 mm, 1/pkg	186007304
XSelect CSH C18 OBD Prep Column, 130?, 10 μm, 50 mm X 50 mm, 1/pkg	186007301
XSelect CSH C18 OBD Prep Column, 130?, 10 μm, 50 mm X 100 mm, 1/pkg	186007302
XSelect CSH C18 OBD Prep Column, 130?, 10 μm, 30 mm X 250 mm, 1/pkg	186007300