2004年，分離科學由于超高效液相色譜技術（Ultra-Performance Liquid Chromatography，UPLC?）的問世而發生了巨大的革命，在儀器和色譜柱方面的顯著進步實現了液相色譜在分離度、靈敏度和速度方面的巨大跨越。一體化設計的ACQUITY UPLC?系統和ACQUITY UPLC色譜柱允許分析人員使用亞2微米顆粒色譜柱，以滿足和克服分析試驗室所面臨的挑戰，使分析科學家們更成功，業務收益更大、產出更多。
CSH技術的優勢包括：
l 對于堿性化合物的優越峰形
l 提高載量
l 更換流動相pH后柱再平衡速度快
l 改善的批次之間重現性
l 在低pH和高pH條件下優異的穩定性
CSH顆粒技術也具有HPLC粒徑產品(2.5,3.5和5微米)，對應于XSelectCSH HPLC柱家族，這確保在HPLC和UPLC技術平臺之間方法可無縫轉換。
ACQUITY UPLC CSH C18柱克服了大多數現代C18柱在低離子強度流動相條件下(如0.1%甲酸體系)因載量所導致的峰形差問題。因帶有嚴格控制下的、低水平的正表面電荷，ACQUITY UPLC CSH C18柱為堿性化合物提供峰形，而無需使用離子對試劑。
目的建立超高效液相-紫外光電二極管陣列檢測-串聯四級桿-飛行時間質譜(UPLC-DAD/Q-TOF-MS)法分析左金丸化學成分。方法分析采用Waters ACQUITY UPLC CSH C18色譜柱(2.1 mm×100 mm,1.7μm);柱溫20℃;流動相0.1%甲酸-0.1%甲酸乙腈,梯度洗脫;體積流量0.2 m L/min;檢測波長222 nm;飛行時間質譜,正離子掃描模式。通過對照品比對,以及質譜、光譜數據進行分析。結果從中鑒定出19種成分,其中11種屬于黃連,8種屬于吳茱萸。結論該方法快速高效,可用于左金丸的質量控制。
品名 | 編號 |
ACQUITY - Xselect CSH C18 Method Transfer Kit, 130?, 1.7 - 3.5 μm, 2.1 - 4.6 mm X 100 - 150mm, 2/... | 186005535 |
ACQUITY - Xselect CSH C18 Method Transfer Kit, 130?, 1.7 - 3.5 μm, 2.1 - 4.6 mm X 50 - 100mm, 2/p... | 186005532 |
ACQUITY PREMIER CSH C18 Column 1.7 μm, 2.1 x 50 mm, 1/pk | 186009460 |
ACQUITY PREMIER CSH C18 Column 1.7 μm, 2.1 x 100 mm, 1/pk | 186009461 |
ACQUITY PREMIER CSH C18 Column 1.7 μm, 2.1 x 150 mm, 1/pk | 186009462 |
ACQUITY PREMIER CSH C18 Column with VanGuard FIT, 1.7 μm, 2.1 x 50 mm, 1/pk | 186009463 |
ACQUITY PREMIER CSH C18 Column with VanGuard FIT, 1.7 μm, 2.1 x 100 mm, 1/pk | 186009464 |
ACQUITY PREMIER CSH C18 Column with VanGuard FIT, 1.7 μm, 2.1 x 150 mm, 1/pk | 186009465 |
ACQUITY PREMIER CSH C18 VanGuard FIT Cartridge, 1.7 μm, 2.1 x 5 mm, 3/pk | 186009466 |
ACQUITY PREMIER Peptide CSH C18 Column, 130?, 1.7 μm, 2.1 x 150 mm, 1/pk | 186009489 |
ACQUITY PREMIER Peptide CSH C18 Column, 130?, 1.7 μm, 2.1 x 100 mm, 1/pk | 186009488 |
ACQUITY PREMIER Peptide CSH C18 Column, 130?, 1.7 μm, 2.1 x 50 mm, 1/pk | 186009487 |
ACQUITY UPLC CSH C18 Column, 130?, 1.7 μm, 1 mm X 100 mm, 1/pkg | 186005293 |
ACQUITY UPLC CSH C18 Column, 130?, 1.7 μm, 3 mm X 75 mm, 1/pkg | 186005623 |
ACQUITY UPLC CSH C18 Column, 130?, 1.7 μm, 2.1 mm X 150 mm, 1/pkg | 186005298 |
ACQUITY UPLC CSH C18 Column, 130?, 1.7 μm, 2.1 mm X 30 mm, 1/pkg | 186005295 |
ACQUITY UPLC CSH C18 Column, 130?, 1.7 μm, 2.1 mm X 50 mm, 1/pkg | 186005296 |
ACQUITY UPLC CSH C18 Column, 130?, 1.7 μm, 3 mm X 30 mm, 1/pkg | 186005299 |
ACQUITY UPLC CSH C18 Column, 130?, 1.7 μm, 2.1 mm X 30 mm, 3/pkg | 176002139 |
ACQUITY UPLC CSH C18 Column, 130?, 1.7 μm, 1 mm X 150 mm, 3/pkg | 176002138 |
ACQUITY UPLC CSH C18 Column, 130?, 1.7 μm, 3 mm X 50 mm, 1/pkg | 186005300 |
ACQUITY UPLC CSH C18 Column, 130?, 1.7 μm, 1 mm X 150 mm, 1/pkg | 186005294 |
ACQUITY UPLC CSH C18 Column, 130?, 1.7 μm, 1 mm X 100 mm, 3/pkg | 176002137 |
ACQUITY UPLC CSH C18 Column, 130?, 1.7 μm, 3 mm X 150 mm, 1/pkg | 186005302 |
ACQUITY UPLC CSH C18 Column, 130?, 1.7 μm, 1 mm X 50 mm, 3/pkg | 176002136 |
ACQUITY UPLC CSH C18 Column, 130?, 1.7 μm, 1 mm X 50 mm, 1/pkg | 186005292 |
ACQUITY UPLC CSH C18 Column, 130?, 1.7 μm, 3 mm X 100 mm, 1/pkg | 186005301 |
ACQUITY UPLC CSH C18 Column, 130?, 1.7 μm, 2.1 mm X 75 mm, 1/pkg | 186005620 |
ACQUITY UPLC CSH C18 Method Validation Kit, 130?, 1.7 μm, 2.1 mm X 100 mm, 3/pkg | 186005572 |
ACQUITY UPLC CSH C18 Column, 130?, 1.7 μm, 3 mm X 150 mm, 3/pkg | 176002146 |
ACQUITY UPLC CSH C18 Column, 130?, 1.7 μm, 3 mm X 100 mm, 3/pkg | 176002145 |
ACQUITY UPLC CSH C18 Column, 130?, 1.7 μm, 2.1 mm X 50 mm, 3/pkg | 176002140 |
ACQUITY UPLC CSH C18 Column, 130?, 1.7 μm, 3 mm X 30 mm, 3/pkg | 176002143 |
ACQUITY UPLC CSH C18 Method Validation Kit, 130?, 1.7 μm, 2.1 mm X 150 mm, 3/pkg | 186006016 |
ACQUITY UPLC CSH C18 Column, 130?, 1.7 μm, 3 mm X 50 mm, 3/pkg | 176002144 |
ACQUITY UPLC CSH C18 Column, 130?, 1.7 μm, 2.1 mm X 100 mm, 3/pkg | 176002141 |
ACQUITY UPLC CSH C18 Column, 130?, 1.7 μm, 2.1 mm X 150 mm, 3/pkg | 176002142 |
ACQUITY UPLC CSH C18 VanGuard Pre-column, 130?, 1.7 μm, 2.1 mm X 5 mm, 3/pkg | 186005303 |
ACQUITY UPLC CSH C18 Method Validation Kit, 130?, 1.7 μm, 3 mm X 100 mm, 3/pkg | 186005574 |
ACQUITY UPLC CSH C18 Method Validation Kit, 130?, 1.7 μm, 2.1 mm X 50 mm, 3/pkg | 186005571 |
ACQUITY UPLC CSH C18 Method Validation Kit, 130?, 1.7 μm, 3 mm X 50 mm, 3/pkg | 186005573 |
ACQUITY UPLC Peptide CSH C18 Column, 130?, 1.7 μm, 1 mm X 100 mm, 1/pkg | 186006934 |
ACQUITY UPLC Peptide CSH C18 Column Kit, 130?, 1.7 μm, 1 mm X 50 mm, 1/pkg | 176003061 |
ACQUITY UPLC Peptide CSH C18 Column Kit, 130?, 1.7 μm, 1 mm X 100 mm, 1/pkg | 176003062 |
ACQUITY UPLC Peptide CSH C18 Column Kit, 130?, 1.7 μm, 1 mm X 150 mm, 1/pkg | 176003063 |
ACQUITY UPLC Peptide CSH C18 Column Kit, 130?, 1.7 μm, 2.1 mm X 50 mm, 1/pkg | 176003064 |
ACQUITY UPLC Peptide CSH C18 Column Kit, 130?, 1.7 μm, 2.1 mm X 100 mm, 1/pkg | 176003065 |
ACQUITY UPLC Peptide CSH C18 Column Kit, 130?, 1.7 μm, 2.1 mm X 150 mm, 1/pkg | 176003066 |
ACQUITY UPLC Peptide CSH C18 Column Kit, Method Validation Kit, 130?, 1.7 μm, 2.1 mm X 150 mm, 3... | 176003068 |
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